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Progressive Supranuclear Palsy

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-diseases-progressive-supranuclear-p
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slugdiseases-progressive-supranuclear-palsy
entity_typedisease
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Linked Artifacts (207)
mentions🧪Smartphone-Detected Motor Variability Correction65%
mentions🧪Selective HDAC3 Inhibition with Cognitive Enhancement65%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption65%
mentions🧪Noradrenergic-Tau Propagation Blockade65%
mentions🧪Microglial Purinergic Reprogramming65%
mentions🧪Sphingolipid Metabolism Reprogramming65%
mentions🧪Synaptic Vesicle Tau Capture Inhibition65%
mentions🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis65%
mentions🧪Glial Glycocalyx Remodeling Therapy65%
mentions🧪Aquaporin-4 Polarization Rescue65%
mentions🧪Ephrin-B2/EphB4 Axis Manipulation65%
mentions🧪Phase-Separated Organelle Targeting65%
mentions🧪Trans-Synaptic Adhesion Molecule Modulation65%
mentions🧫s:** - Test tau spreading in AQP4 knockout vs wild-type mice60%
mentions🧫4R-Tau Targeting Therapies for PSP and CBS60%
mentions🧫Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy60%
mentions🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri60%
mentions🧫Brainstem Circuit Modulation for PSP60%
mentions🧫CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi60%
mentions🧫CRISPR Gene Correction Approaches for CBS/PSP60%
mentions🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre60%
mentions🧫N-of-1 Clinical Trial Design for CBS/PSP60%
mentions🧫PSP and CBS Biomarker Validation Study60%
mentions🧫Tau Pathology Initiation Zone Identification60%
mentions🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo60%
mentions🧫Tau Spreading Network Mapping via Spatial Transcriptomics in60%
mentions🧫Tau ASO Therapy60%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr60%
related🧫Metabolic Pathway-Targeted Therapy in ALS60%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker60%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model60%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk60%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri60%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring60%
related🧫Brainstem Circuit Modulation for PSP60%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT60%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study60%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen60%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio60%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design60%
related🧫N-of-1 Clinical Trial Design for CBS/PSP60%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers60%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic60%
related🧫Progranulin Replacement Therapy for FTD — Vector Development60%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD60%
related🧫PSP and CBS Biomarker Validation Study60%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen60%
related🧫TDP-43 PET Ligand Development for FTD and ALS60%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des60%
related🧪Smartphone-Detected Motor Variability Correction58%
related🧪SASP-Mediated Cholinergic Synapse Disruption58%
related🧪Noradrenergic-Tau Propagation Blockade58%
related🧪Microglial Purinergic Reprogramming58%
related🧪Sphingolipid Metabolism Reprogramming58%
related🧪Synaptic Vesicle Tau Capture Inhibition58%
related🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis58%
related🧪Glial Glycocalyx Remodeling Therapy58%
related🧪Aquaporin-4 Polarization Rescue58%
related🧪Ephrin-B2/EphB4 Axis Manipulation58%
related🧪Phase-Separated Organelle Targeting58%
related🧪Trans-Synaptic Adhesion Molecule Modulation58%
mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr55%
mentions🧫Metabolic Pathway-Targeted Therapy in ALS55%
mentions🧫ALS Progression Rate Heterogeneity — mechanism and biomarker55%
mentions🧫ALS Regional Onset and Spread: Network-Level Staging Model55%
mentions🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk55%
mentions🧫Blood Biomarker vs Tau PET for Treatment Monitoring55%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT55%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study55%
mentions🧫Environmental Exposure Causal Attribution in ALS — Experimen55%
mentions🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio55%
mentions🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design55%
mentions🧫Pre-Symptomatic Detection and Intervention Timing in Genetic55%
mentions🧫Progranulin Replacement Therapy for FTD — Vector Development55%
mentions🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD55%
mentions🧫Sleep and Respiratory Network Interaction in ALS — Experimen55%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS55%
mentions🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des55%
related🧫s:** - Test tau spreading in AQP4 knockout vs wild-type mice54%
related🧫4R-Tau Targeting Therapies for PSP and CBS54%
related🧫Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy54%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri54%
related🧫Brainstem Circuit Modulation for PSP54%
related🧫CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi54%
related🧫CRISPR Gene Correction Approaches for CBS/PSP54%
related🧫Levodopa Response Determinants in PSP — Biomarker-Guided Pre54%
related🧫N-of-1 Clinical Trial Design for CBS/PSP54%
related🧫PSP and CBS Biomarker Validation Study54%
related🧫Tau Pathology Initiation Zone Identification54%
related🧫Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo54%
related🧫Tau Spreading Network Mapping via Spatial Transcriptomics in54%
related🧫Tau ASO Therapy54%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr54%
related🧫Metabolic Pathway-Targeted Therapy in ALS54%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker54%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model54%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk54%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring54%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT54%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study54%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen54%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio54%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design54%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers54%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic54%
related🧫Progranulin Replacement Therapy for FTD — Vector Development54%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD54%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des54%
mentions🧫Experiment: Multi-Ethnic PD GWAS50%
mentions🧫Microtubule domain analysis in adult axons50%
mentions🧫Tau depletion effects on neuronal development in primary cul50%
mentions🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying sleep disruption as cause50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬What are the mechanisms underlying sleep disruption as cause50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
related🧪APOE Isoform Expression Across Glial Subtypes50%
mentions📖AAIC 2026: Tau Immunotherapy40%
mentions📖Adam L. Boxer40%
mentions📖Alexei Mikhailov40%
mentions📖Amylyx Pharmaceuticals, Inc.40%
mentions📖Angelo Antonini, MD, PhD — Movement Disorder Specialist40%
mentions📖Autotac Bio Inc.40%
mentions📖Biotie Therapies40%
mentions📖Bradley F. Boeve40%
mentions📖Brian Roels — PSP Neuropathology Researcher40%
mentions📖Bukwang Pharmaceutical40%
mentions📖CIEN Foundation40%
mentions📖Carlo Ferraro — Movement Disorder Researcher40%
mentions📖Cegedim40%
mentions📖Charité – Universitätsmedizin Berlin40%
mentions📖Chiara Marsili — PSP Researcher40%
mentions📖Christopher Churchman40%
mentions📖CurePSP - Foundation for Progressive Supranuclear Palsy40%
mentions📖CurePSP — International PSP Foundation40%
mentions📖David Irwin40%
mentions📖Dennis W. Dickson — Leading Neuropathologist40%
mentions📖Eduardo Tolosa — PSP Researcher40%
mentions📖Ferrer Internacional40%
mentions📖Günter Höglinger40%
mentions📖Harvard Medical School40%
mentions📖Hirofumi Yoshino — Tauopathy Researcher40%
mentions📖Huw Morris40%
mentions📖IXICO Technologies40%
mentions📖Invicro40%
mentions📖Irene Litvan40%
mentions📖James Boxer40%
mentions📖James Leverenz40%
mentions📖James Rowe40%
mentions📖Jennifer L. Whitwell40%
mentions📖John E. Duda — Neuropathology Researcher40%
mentions📖John R. Hodges40%
mentions📖Kailash Bhatia40%
mentions📖Keith A. Josephs40%
mentions📖Kyowa Kirin Co., Ltd.40%
mentions📖Lauren Shore40%
mentions📖Lawrence Golbe40%
mentions📖Lea T. Grinberg40%
mentions📖Marc H. Smith40%
mentions📖Marc Hutton40%
mentions📖Maria Bernardino — PSP Researcher40%
mentions📖Masahiro Kato — PSP Researcher40%
mentions📖Movement Disorder Specialists Directory40%
mentions📖Nicola Ray — Movement Disorder Researcher40%
mentions📖Nicolas Lambrecq40%
mentions📖Oligomerix, Inc.40%
mentions📖PD Neurotechnology40%
mentions📖Patricia Martinez — PSP Clinical Trials Researcher40%
mentions📖Pinteon40%
mentions📖Reo40%
mentions📖Rohit Das — Movement Disorder Specialist40%
mentions📖Ryan Darby40%
mentions📖Sarah Chen — Clinical PSP Researcher40%
mentions📖Sonia Koyama — Tauopathy Researcher40%
mentions📖Tetsuya Kimura40%
mentions📖Toyo Biotechnology40%
mentions📖University of British Columbia40%
mentions📖University of California Santa Barbara40%
mentions📖University of Cincinnati40%
mentions📖University of Texas Southwestern40%
mentions📖University of Toronto40%
mentions📖Werner Poewe — International Movement Disorder Expert40%
mentions📖William W. Seeley40%
mentions📖dzne40%
mentions📖uni-washington40%
mentions📖university-of-rochester40%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
mentions🔬What are the mechanisms underlying protein aggregation cross40%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,40%
related🧪Selective HDAC3 Inhibition with Cognitive Enhancement40%
related🔬What are the mechanisms underlying 4r-tau strain-specific sp39%
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