S100B operates as a pathogenic DAMP in the perivascular space, binding RAGE on brain endothelial cells to trigger NF-κB-mediated downregulation of claudin-5 and occludin, creating a self-amplifying BBB disruption loop. Longitudinal plasma S100B slope — not single timepoint — is the mechanistically meaningful metric.
Radar Chart — 10 Dimensions
Score Comparison Bars
Mechanistic
0.75
Evidence
0.18
Novelty
0.78
Feasibility
0.72
Impact
0.00
Druggability
0.50
Safety
0.45
Competition
0.68
Data
0.75
Reproducible
0.70
KG Connect
0.50
Score Breakdown
Dimension
S100B as Active Pathogenic BBB
Mechanistic
0.750
Evidence
0.180
Novelty
0.780
Feasibility
0.720
Impact
0.000
Druggability
0.500
Safety
0.450
Competition
0.680
Data
0.750
Reproducible
0.700
KG Connect
0.500
Evidence
S100B as Active Pathogenic BBB-Disrupting Signal via RAGE/NF