Pipeline Observability

Flow rates across the six-stage SciDEX mission pipeline

JSON Updated: 2026-06-17 14:53 UTC
🗺 Landscapes
3
0 new (7d)
→ next stage 100.0%
SLA: 7d None stuck
🔍 Gaps 10 stuck
3,545
0 new (7d)
→ next stage 0.9%
SLA: 30d 76d old
🗣 Debates 10 stuck
915
0 new (7d)
→ next stage 51.1%
SLA: 3d 76d old
🧬 Hypotheses 10 stuck
2,408
0 new (7d)
→ next stage 57.6%
SLA: 14d 76d old
🏆 Ranked 10 stuck
1,388
0 new (7d)
→ next stage 26.3%
SLA: 30d 76d old
🎯 Challenges / Experiments 10 stuck
1,000
0 new (7d)
→ next stage 10.9%
SLA: 45d 74d old
≥60% throughput
25–60% throughput
<25% throughput
N stuck= items past SLA

Stuck Items   50 stuck items across all stages

🔍 Gaps 10 stuck status=open/proposed, never debated after 30 days View all →
Item Created Age Score
Test 2026-04-25 52d priority: 0.90
What is the diagnostic specificity and sensitivity of motor band sign on 18F-FDG 2026-04-10 67d priority: 0.87
Will the cognitive benefits of JAK inhibition in HAND translate from mouse model 2026-04-11 67d priority: 0.87
How does calcium dysregulation at synapses contribute to AD and PD synaptopathy? 2026-04-10 67d priority: 0.86
Should tau-targeted therapies be redesigned to account for Aβ-tau synergy rather 2026-04-10 67d priority: 0.86
How do specific microbial metabolites affect CNS cell function during neuroinfla 2026-04-10 67d priority: 0.86
How do UCH-mediated ubiquitination imbalances differentially drive cancer versus 2026-04-10 67d priority: 0.86
How do roscovitine and tamoxifen's different mechanisms both effectively reduce 2026-04-10 67d priority: 0.86
How does gastrointestinal inflammation causally contribute to alpha-synuclein pa 2026-04-10 67d priority: 0.86
How can glymphatic imaging biomarkers be validated for diagnostic use in neurode 2026-04-11 67d priority: 0.86
🗣 Debates 10 stuck Debate generated 0 hypotheses after 3 days View all →
Item Created Age Score
Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi 2026-04-02 76d quality: 0.46
Is disrupted sleep a cause or consequence of neurodegeneration? Analyze the bidi 2026-04-02 76d quality: 0.59
Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma 2026-04-02 76d quality: 0.49
What gene expression changes in the aging mouse brain predict neurodegenerative 2026-04-02 76d quality: 0.57
What gene expression changes in the aging mouse brain predict neurodegenerative 2026-04-02 76d quality: 0.50
What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc 2026-04-02 76d quality: 0.56
What gene expression changes in the aging mouse brain predict neurodegenerative 2026-04-02 76d quality: 0.43
Analyze circuit-level changes in neurodegeneration using Allen Institute Neural 2026-04-02 76d quality: 0.42
Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s 2026-04-02 76d quality: 0.55
What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc 2026-04-02 76d quality: 0.57
🧬 Hypotheses 10 stuck composite_score < 0.5 after 14 days View all →
Item Created Age Score
Enteric Nervous System Prion-Like Propagation Blockade 2026-04-02 76d composite: 0.48
Microbiome-Derived Tryptophan Metabolite Neuroprotection 2026-04-02 76d composite: 0.43
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis 2026-04-02 76d composite: 0.38
Microglia-Derived Extracellular Vesicle Engineering for Targeted Mitochondrial D 2026-04-02 75d composite: 0.48
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption 2026-04-02 75d composite: 0.47
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding 2026-04-02 75d composite: 0.47
Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange 2026-04-02 75d composite: 0.36
Optogenetic Control of Mitochondrial Transfer Networks 2026-04-02 75d composite: 0.48
Test: TREM2 enhances amyloid clearance 2026-04-04 74d composite: 0.40
Conditional CRISPR Kill Switches for Aberrant Protein Clearance 2026-04-04 73d composite: 0.50
🏆 Ranked 10 stuck Ranked hypothesis not linked to any challenge after 30 days View all →
Item Created Age Score
HSP90-cochaperone complexes preferentially stabilize intermediate misfolded stat 2026-04-28 49d composite: 0.84
J-protein substrate specificity codes enable HSP70 discrimination of β-sheet ver 2026-04-28 49d composite: 0.84
Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization 2026-04-28 49d composite: 0.83
CREB-Dependent Differential Complement Regulator Positioning for Activity-Based 2026-04-28 49d composite: 0.83
J-protein co-chaperone system mediates selective autophagy targeting of pathogen 2026-04-28 49d composite: 0.83
TDP-43 RNA-proteostasis failure across ALS, FTD, and AD/LATE 2026-04-28 49d composite: 0.83
Gamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaff 2026-04-28 49d composite: 0.83
SNCA conformer propagation across PD, DLB, and MSA 2026-04-28 49d composite: 0.82
Autophagy-Lysosomal Pathway Dysfunction as a Unifying Proteostasis Failure 2026-04-28 49d composite: 0.82
CYP46A1 Small Molecule Activator Therapy 2026-04-28 49d composite: 0.82
🎯 Challenges / Experiments 10 stuck Open challenge with no linked experiment after 45 days View all →
Item Created Age Score
Engineering Improved Blood-Brain Barrier Penetrance for Antibody Therapeutics in 2026-04-17 60d composite: 0.89
Therapeutic Targeting of TDP-43 Phase Separation in ALS-FTD 2026-04-17 60d composite: 0.84
Therapeutic Correction of APOE4 Structure and Function in Alzheimer's Disease 2026-04-17 60d composite: 0.83
Nutrient-Sensing Epigenetic Circuit Reactivation to Restore Neuronal Resilience 2026-04-17 60d composite: 0.84
Breaking the GBA—α-Synuclein Bidirectional Feedback Loop in Parkinson's Disease 2026-04-17 60d composite: 0.82
Senolytic Therapy for Age-Related Neurodegeneration: Target Cell Selectivity and 2026-04-17 60d composite: 0.80
ACSL4-Driven Ferroptosis in Disease-Associated Microglia: Therapeutic Opportunit 2026-04-17 60d composite: 0.80
TREM2 Agonism vs Antagonism in Disease-Associated Microglia 2026-04-17 60d composite: 0.81
Convergent Autophagy-Lysosome Pathway Therapeutics Across Neurodegenerative Dise 2026-04-17 60d composite: 0.80
Characterizing and Interrupting Microglia-Astrocyte Neuroinflammatory Amplificat 2026-04-17 60d composite: 0.78
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