TDP-43 AGGREGATION

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 AGGREGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    TDP_43_AGGREGATION["TDP-43 AGGREGATION"]
    TDP_43_AGGREGATION -->|"causes"| Neurodegeneration["Neurodegeneration"]
    TDP_43_AGGREGATION -->|"contributes to"| Als_Pathology["Als Pathology"]
    TDP_43_AGGREGATION -->|"contributes to"| Ftd_Pathology["Ftd Pathology"]
    TDP_43_AGGREGATION -->|"mediates"| TDP_43_Loss_Of_Function["TDP-43 Loss Of Function"]
    TDP_43_AGGREGATION -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    TDP_43_AGGREGATION -->|"interacts"| TDP_43_Mislocalization["TDP-43 Mislocalization"]
    p38__MAPK_inhibition["p38alpha MAPK inhibition"] -->|"reduces"| TDP_43_AGGREGATION
    oxidative_stress["oxidative stress"] -->|"promotes"| TDP_43_AGGREGATION
    SUMO2_3_conjugation["SUMO2/3 conjugation"] -.protects against.-> TDP_43_AGGREGATION
    TARDBP["TARDBP"] -->|"involved_in"| TDP_43_AGGREGATION
    cAMP_PKA_Signaling["cAMP/PKA Signaling"] -->|"modulates"| TDP_43_AGGREGATION
    Loss_Of_ASRGL1["Loss Of ASRGL1"] -->|"causes"| TDP_43_AGGREGATION
    Oxidative_Stress["Oxidative Stress"] -->|"activates"| TDP_43_AGGREGATION
    ASRGL1["ASRGL1"] -->|"inhibits"| TDP_43_AGGREGATION