Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Neurodegeneration: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Neurodegeneration is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Alzheimer. Connected to 3156 entities in the SciDEX knowledge graph.
| Associated Genes | LRP8, LRP5, LRP1, LRP2, LRP1B, LRP4, PAH, LDLR |
| Therapeutic Agents | LXR Agonist, MTOR Inhibitors, Isr Potentiators, Glp-1 Receptor Agonists, Rapamycin, Brilliant Blue G |
| SciDEX Hypotheses | 328 hypotheses |
| KG Connections | 6175 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
Neurodegeneration["Neurodegeneration"] -->|"regulates"| Apoptosis["Apoptosis"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Mtor["Mtor"]
Neurodegeneration["Neurodegeneration"] -->|"activates"| Autophagy["Autophagy"]
MTOR["MTOR"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
APOE["APOE"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
APOE_2["APOE"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
PINK1["PINK1"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
LC3["LC3"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
PTEN["PTEN"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
end
subgraph Therapeutic["Therapeutic"]
Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Blood_Brain_Barrier["Blood-Brain Barrier"]
Neurodegeneration["Neurodegeneration"] -->|"therapeutic target"| Autophagy_1["Autophagy"]
end
subgraph Pathology["Pathology"]
Neurodegeneration["Neurodegeneration"] -->|"associated with"| Alzheimer["Alzheimer"]
Neurodegeneration["Neurodegeneration"] -->|"associated with"| Inflammation["Inflammation"]
Neurodegeneration["Neurodegeneration"] -->|"associated with"| Senescence["Senescence"]
Neurodegeneration["Neurodegeneration"] -->|"associated with"| Dementia["Dementia"]
end
style Neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style Apoptosis fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Blood_Brain_Barrier fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Senescence fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Dementia fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy_1 fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style LC3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Apoptosis | regulates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Blood-Brain Barrier | therapeutic_target | pathway | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Proteasome | activates | pathway | 1.00 |
| Mtor | associated_with | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Synaptic Plasticity | activates | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Blood-Brain Barrier | activates | pathway | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Mitochondrial Function | therapeutic_target | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Complement | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Oxidative Stress | contributes_to | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Oxidative Stress | associated_with | pathway | 1.00 |
| Neurogenesis | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Mitophagy | associated_with | pathway | 1.00 |
| Proteasome | therapeutic_target | pathway | 1.00 |
| Mitophagy | therapeutic_target | pathway | 1.00 |
| Ubiquitin-Proteasome | therapeutic_target | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Autophagy | causes | pathway | 1.00 |
| Apoptosis | causes | pathway | 1.00 |
| Senescence | activates | pathway | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Stem Cell | activates | pathway | 1.00 |
| Dementia | activates | disease | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Alzheimer | implicated_in | disease | 1.00 |
| Autophagy | implicated_in | pathway | 1.00 |
| Alzheimer | causes | disease | 1.00 |
| Dementia | causes | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | activates | gene | 1.00 |
| APOE | activates | gene | 1.00 |
| APOE | regulates | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| JUN | activates | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| MTOR | associated_with | gene | 1.00 |
| GAIN | activates | gene | 1.00 |
| TREM2 | associated_with | gene | 1.00 |
| GFAP | biomarker_for | gene | 1.00 |
| OVERVIEW | activates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| APOE | associated_with | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Stroke | associated_with | disease | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| P62 | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| APOE4 | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Dementia | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| DNA | associated_with | gene | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| P53 | activates | gene | 1.00 |
| Tauopathy | associated_with | disease | 1.00 |
| MITOCHONDRIAL DNA | activates | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| AMPK | activates | gene | 1.00 |
| DNA | regulates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Cardiovascular | associated_with | disease | 1.00 |
| PARKIN | therapeutic_target | gene | 1.00 |
| APP | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| OVERVIEW | associated_with | gene | 1.00 |
| BDNF | associated_with | gene | 1.00 |
| OPTN | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.562
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Mapping the immune landscape of PCa: From tumor microenvironment to therapeutics [PMID:41956336] | Huang S, Ou Y, Zhuang W, Huang J, Wang B | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412] | Villani A, Wittmann J, Wyss T, Mallona I | Commun Biol | 2026 | 0 |
| Nlrc4 Inflammasome Expression After Acute Myocardial Infarction in Rats. [PMID:40332346] | Borim PA, Gatto M, Mota GAF, Meirelles A | Int J Mol Sci | 2025 | 0 |
| Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impair [PMID:33584302] | Huang S, Liu H, Lin Y, Liu M, Li Y et al | Front Pharmacol | 2020 | 0 |
| Inflammasome and toll-like receptor signaling in human monocytes after successfu [PMID:27260481] | Asmussen A, Fink K, Busch HJ, Helbing T, | Crit Care | 2016 | 0 |
| Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is respon [PMID:24879148] | Guo W, Sun Y, Liu W, Wu X, Guo L et al. | Autophagy | 2014 | 0 |
| Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376] | Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa | 1993 | 0 |