disease

Amyotrophic Lateral Sclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Amyotrophic Lateral Sclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5729Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Amyotrophic Lateral Sclerosis is a disease characterized by neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Aging, Als, Als4. Connected to 1395 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	STIP1, LGALS3, HSPA8, MCOLN1, SQSTM1, SOD1, BCL2, CTSB
Therapeutic Agents	Antisense oligonucleotides, Adeno-associated virus, Gene Silencing Therapies, Tudca, Honokiol, Ropinirole
KG Connections	2496 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ACTB["ACTB"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    OPTN["OPTN"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ULK1["ULK1"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SMCR8["SMCR8"] -->|"interacts"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    style Amyotrophic_Lateral_Sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2447)

Target	Relation	Type	Str
Als	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Alzheimer	associated_with	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
Dementia	associated_with	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Als	causes	disease	1.00
Neurodegeneration	activates	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Neurodegeneration	causes	disease	1.00
Als	implicated_in	disease	1.00
Neurodegeneration	implicated_in	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Motor Neuron Death	causes	process	0.95
Neurodegenerative Process	involved_in	process	0.95
Dementia	causes	disease	0.95
Parkinson	implicated_in	disease	0.95
Alzheimer	implicated_in	disease	0.95
Als	activates	disease	0.95
Neurodegenerative Diseases	associated_with	disease	0.95
Motor Neuron Loss	causes	phenotype	0.95
Upper Motor Neurons	causes	cell_type	0.95
Lower Motor Neurons	causes	cell_type	0.95
Motoneurons	associated_with	cell_type	0.95
Motor Neurons	causes	cell_type	0.95
Corticospinal Motor Neuron Degeneration	causes	phenotype	0.95
Non-Coding Rna	therapeutic_target	compound	0.92
Frontotemporal Dementia	associated_with	disease	0.90
Genetics	associated_with	process	0.90
Pathology	associated_with	process	0.90
ALS Reversal	contributes_to	phenotype	0.90
Phenotypic Overlap	contributes_to	phenotype	0.90
Neurons	targets	cell_type	0.90
Neurodegeneration	involved_in	process	0.90
Upper Motoneuron Involvement	associated_with	phenotype	0.90
Pre-Symptomatic Stage	associated_with	phenotype	0.90
Autophagy	regulates	pathway	0.90
Immune Response	therapeutic_target	pathway	0.90
Oxidative Stress	associated_with	pathway	0.90
Apoptosis	activates	pathway	0.90
Nf-Κb	activates	pathway	0.90
Frontotemporal Lobar Degeneration	associated_with	disease	0.88
Inflammation	associated_with	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Alzheimer	regulates	disease	0.85
Neurodegeneration	regulates	disease	0.85
Aging	implicated_in	disease	0.85

Incoming (3282)

Source	Relation	Type	Str
SOD1	therapeutic_target	gene	1.00
C9ORF72	associated_with	gene	1.00
OPTN	associated_with	gene	1.00
FUS	associated_with	gene	1.00
Als	associated_with	disease	1.00
GENES	activates	gene	1.00
Alzheimer	associated_with	disease	1.00
DNA	interacts_with	gene	1.00
DNA	therapeutic_target	gene	1.00
Parkinson	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
GENES	associated_with	gene	1.00
SOD1	causes	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
ALS	associated_with	gene	1.00
MICROGLIA	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
HUNTINGTON'S DISEASE	associated_with	gene	1.00
NEURODEGENERATIVE DISORDERS	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	1.00
ALS	therapeutic_target	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	biomarker_for	gene	1.00
ALS	biomarker_for	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
PARKINSON'S DISEASE	activates	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	1.00
NEUROINFLAMMATION	therapeutic_target	gene	1.00
MOTOR NEURONS	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
ALS	activates	gene	1.00
ALS	regulates	gene	1.00
ASTROCYTES	activates	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
MOTOR NEURONS	associated_with	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
ALS	interacts_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Amyotrophic Lateral Sclerosis

Understanding Entity Pages

Summary

Wiki Pages (21)