Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Phase Separation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Normal Cell Function | involved_in | phenotype | 0.95 |
| stress granule formation | mediates | process | 0.94 |
| Stress Granules | involved_in | process | 0.90 |
| Stress Granule Formation | involved_in | process | 0.90 |
| Condensate Formation | mediates | mechanism | 0.90 |
| TDP-43 Aggregation | contributes_to | mechanism | 0.90 |
| DDR foci formation | drives | process | 0.90 |
| stress granules | mediates | process | 0.90 |
| protein aggregation | drives | process | 0.90 |
| STAU1 Condensate Formation | involved_in | mechanism | 0.85 |
| PABP1 | associated_with | protein | 0.85 |
| Stress Granule Formation | associated_with | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNAJB6 | regulates | protein | 0.93 |
| Repeat Rna | modulates | compound | 0.90 |
| TDP-43 Misfolding | mediates | mechanism | 0.90 |
| RNA G-quadruplexes | regulates | process | 0.90 |
| Tdp43 Low-Complexity Domain | mediates | protein | 0.90 |
| SYNCRIP | mediates | protein | 0.85 |
| Phosphorylation | associated_with | process | 0.85 |
| Tp53Bp1 | involved_in | protein | 0.85 |
| UBQLN2 | involved_in | protein | 0.85 |
| Chemical Modulators | modulates | compound | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 | 0.598 | neurodegeneration | What is the therapeutic window between i |
| Stress Granule Phase Separation Modulators | 0.490 | neurodegeneration | RNA binding protein dysregulation across |
| Liquid-Liquid Phase Separation Modifier Therapy | 0.416 | neurodegeneration | Protein aggregation cross-seeding across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
medicinal chemistry | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Pre-Symptomatic Detection and Intervention Timing in Genetic Prion Dis | validation | ALS | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Stress Granule Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Experiment Validation: In vitro ThT Assay | validation | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377] | Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba | Hypertension | 2025 | 1 |
| The important role of stress granules in prostate cancer development, progressio [PMID:40972860] | Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X | Gene | 2025 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747] | Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li | Proceedings of the National Ac | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |
| SARS-CoV-2 directly infects the inner ear and causes hearing dysfunction. [PMID:41936052] | Liu X, Zong Y, Liu K, Shi X, Zhao Z et a | Cell Rep | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Frontiers in pharmacology | 2026 | 0 |
| STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183] | Eom E, Kim J, Kim J, Kang SJ | Cell death and differentiation | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201] | Sun H, Yang C, Du J, Xu C, Chen Y, Chen | Cell death & disease | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932] | Mulloy RP, Evseev D, Sharlin N, Bui-Mari | PLoS biology | 2026 | 0 |
| Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-depe [PMID:41935238] | Park DH, Ahn SY, Kim J, Choi J, Lee S et | EMBO Rep | 2026 | 0 |
| Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration. [PMID:40014573] | ["Sahoo P", "Agrawal M", "Hanovice N", " | Proceedings of the National Ac | 2025 | 0 |
| β-propeller protein-associated neurodegeneration protein WDR45 regulates stress [PMID:40473629] | ["Li Y", "Fang J", "Ding Y", "Zhang X", | Nature communications | 2025 | 0 |
| RIOK1 phase separation restricts PTEN translation via stress granules activating [PMID:40467995] | ["Meng F", "Li H", "Huang Y", "Wang C", | Nature cancer | 2025 | 0 |
| Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via [PMID:39936620] | Ding N, Song Y, Zhang Y, Yu W, Li X et a | Autophagy | 2025 | 0 |
| Identification of small molecule inhibitors of G3BP-driven stress granule format [PMID:38284934] | ["Freibaum B", "Messing J", "Nakamura H" | The Journal of cell biology | 2024 | 0 |