concept

TAU PROPAGATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU PROPAGATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
8Hypotheses
4Analyses
2Outgoing
1Incoming

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💡 Concept Info
NameTAU PROPAGATION
Linked Hypotheses8 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Novel Therapy Index

idea · 10647 words

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

Pathway Diagram

graph TD
    TAU_PROPAGATION["TAU PROPAGATION"]
    TAU_PROPAGATION -->|"activates"| TREM2["TREM2"]
    MAPT["MAPT"] -->|"modulates"| TAU_PROPAGATION
    Endosomal_Lysosomal_Pathway["Endosomal-Lysosomal Pathway"] -->|"regulates"| TAU_PROPAGATION
    UFMylation_Cascade["UFMylation Cascade"] -->|"modulates"| TAU_PROPAGATION
    Inhibiting_UFMylation_Cascade["Inhibiting UFMylation Cascade"] -->|"inhibits"| TAU_PROPAGATION
    Exosome_Release["Exosome Release"] -->|"mediates"| TAU_PROPAGATION
    Endolysosomal_Pathway["Endolysosomal Pathway"] -->|"regulates"| TAU_PROPAGATION
    VPS29["VPS29"] -->|"modulates"| TAU_PROPAGATION
    SEEDING["SEEDING"] -->|"causes"| TAU_PROPAGATION

Outgoing (2)

TargetRelationTypeStr
recognition memoryinhibitsprocess0.70
Alzheimer's diseaseassociated_withdisease0.70

Incoming (28)

SourceRelationTypeStr
TAUco_discussedentity0.50

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop tACS targeting EC-II SST interneurons to block t 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress 0.670 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II 0.612 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance 0.578 Alzheimer's disease Circuit-level neural dynamics in neurode
Noradrenergic-Tau Propagation Blockade 0.510 neurodegeneration Sleep disruption as cause and consequenc
Closed-loop transcranial focused ultrasound targeting CA1 PV 0.508 Alzheimer's disease Circuit-level neural dynamics in neurode
Microglial Exosome-Mediated Tau Propagation 0.468 neuroscience Circuit-level neural dynamics in neurode

Mentioning Analyses (4)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

protein folding | 2026-04-06 | 0 hypotheses

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 po [PMID:31227597] Snyder AG, Hubbard NW, Messmer MN, Kofma Sci Immunol 2019 1
Effect of etching with potassium hydrogen difluoride and ammonium hydrogen diflu [PMID:31068549] Akazawa N, Koizumi H, Nogawa H, Kodaira Dent Mater J 2019 1
Synapse formation in the brain can be enhanced by co-administering three specifi [PMID:29031899] Wurtman RJ Eur J Pharmacol 2017 1
Engineered AAVs for efficient noninvasive gene delivery to the central and perip [PMID:28671695] Chan KY, Jang MJ, Yoo BB, Greenbaum A, R Nat Neurosci 2017 1
The Pediatric Imaging, Neurocognition, and Genetics (PING) Data Repository. [PMID:25937488] Jernigan TL, Brown TT, Hagler DJ Jr, Aks Neuroimage 2016 1
Regulation of Lipid Biology-Associated Gene Expression in Granulosa Cells in Hyp [PMID:41605187] ["Berkel C"] Lipids 2026 0
Meta-GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammali [PMID:41504393] ["Lin Q", "Cai X", "Zhong Z", "Li T", "C Advanced science (Weinheim, Ba 2026 0
Necl1 deficiency induces noradrenergic dysfunction and depressive-like states in [PMID:41308882] ["Song J", "Wang L", "Suo J", "Ran K", " Journal of affective disorders 2026 0
The contribution of phenolic endocrine-disrupting chemicals to breast cancer ris [PMID:41673191] ["Dou Y", "Li X", "Li M", "Shang J", "Xu Scientific reports 2026 0
Transcriptomics reveals new therapeutic targets for ovarian cancer. [PMID:41577183] ["Feng Y", "Liu G"] SLAS technology 2026 0
Noradrenergic inhibition of definitive POMC neurons through direct and indirect [PMID:41877438] Lavoie O, Turmel A, Khouma A, Minbashi M Journal of neuroendocrinology 2026 0
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] Yang S, Wang X, Yan Y, Zhang J, Wei Y et J Affect Disord 2026 0
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361] Han SC, Han J, Min YK, Han JW, Jeong HJ Am J Sports Med 2026 0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] Vadalà A, Benelli C, Suraci F, Carta B, Arch Orthop Trauma Surg 2026 0
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967] Huang X, Francis I, Gu Y, Saha SC Respir Physiol Neurobiol 2026 0
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313] Samante FI, Galangue CG, Avelino DC, Bel Pharmacol Rep 2026 0
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213] Wu J, Lin B, Yang S, Xu S, Li S J Prosthet Dent 2026 0
The Neuroimmunome of Hepatitis Patients Associates With Disease Severity. [PMID:41347690] ["N\u00f3bile A", "Adri A", "Usuda J", " Journal of medical virology 2025 0
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Fe [PMID:39137067] ["Kobayashi H", "Iida T", "Ochiai Y", "M Cancer discovery 2025 0
Molecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and [PMID:41058112] ["Santos A", "de Souza T", "Aguiar K", " American journal of medical ge 2025 0