gene 4,687 words KG: APOC4 2026-03-27
kind:genesection:genesstate:published
Contents

APOC4 — Apolipoprotein C-IV

🧬 Gene Info
Gene SymbolAPOC4
Full NameApolipoprotein C-IV
Chromosome19q13.32
Functionis a small (≈17 kDa) exchangeable apolipoprotein that can transfer between different lipoprotein particles.
Primary Expressionthe liver and, to a lesser extent, in the brain, where it participates in triglyceride-rich lipoprotein metabolism and may influence neurodegenerative
Molecular Weight17 kDa
Amino Acids146 aa
Exons4
UniProt IDP55056
NCBI Gene ID345
Ensembl IDENSG00000224259
OMIM607789
GeneCardsAPOC4
Human Protein AtlasAPOC4
TissueExpression Level
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
APOE Isoform Conversion Therapy
Score: 0.44
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60

Related Analyses (2)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 4 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

APOC4 data_in benchmark_ot_ad_answer_key:APOC4
benchmark_ot_ad_answer_key:APOC4 data_in APOC4