gene 4,687 words KG: APOC4
Contents

APOC4 — Apolipoprotein C-IV

🧬 Gene Info
Gene SymbolAPOC4
Full NameApolipoprotein C-IV
Chromosome19q13.32
Functionis a small (≈17 kDa) exchangeable apolipoprotein that can transfer between different lipoprotein particles.
Primary Expressionthe liver and, to a lesser extent, in the brain, where it participates in triglyceride-rich lipoprotein metabolism and may influence neurodegenerative
Molecular Weight17 kDa
Amino Acids146 aa
Exons4
UniProt IDP55056
NCBI Gene ID345
Ensembl IDENSG00000224259
OMIM607789
GeneCardsAPOC4
Human Protein AtlasAPOC4
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (31)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
APOE Isoform Conversion Therapy
Score: 0.72
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
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Related Analyses (2)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
APOE4 (Apolipoprotein E4)
disease · Pages share 4 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 4 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 4 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (2 edges)

APOC4 data_in benchmark_ot_ad_answer_key:APOC4
benchmark_ot_ad_answer_key:APOC4 data_in APOC4

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