disease 12,907 words KG: PSP 2026-03-24
kind:diseasesection:diseasesstate:publishedevidence:strong
Contents

Progressive Supranuclear Palsy (PSP)

Disease Info
Globose neurofibrillary tanglesLocated in subcortical nuclei including the Subthalamic Nucleus (STN), Globus Pallidus (GP), substantia nigra (SN), and brainstem raphe nuclei[^7]
Tufted astrocytesAstrocytic inclusions specific to PSP, arranged in tufts around the nucleus
Coiled bodiesOligodendroglial inclusions in the white matter
Thread-like processesTau-positive neurites in the neuropil
Associated GenesDUSP10, MAP1S, TAU, CDKN2A, PI3K, MAPT, PSMB7, GBA
KG Connections292 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Knowledge Graph

Related Hypotheses (29)

Microglial Purinergic Reprogramming
Score: 0.48
Glial Glycocalyx Remodeling Therapy
Score: 0.41
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.40
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.34
Glymphatic-Mediated Tau Clearance Dysfunction
Score: 0.55

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (30)

4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.46
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.46
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.46
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.46
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.46

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
PSP activates VPS29
PSP activates MAPT
PSP activates GAL