Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about microglial_dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| PLCG2 Allosteric Modulation as a Precision Therapeutic for T | 0.941 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
| TREM2-Mediated Microglial Dysfunction Disrupts Perivascular | 0.812 | neuroscience | TREM2 in Alzheimer's Disease: Mechanisms |
| TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy | 0.691 | neuroscience | Circuit-level neural dynamics in neurode |
| TREM2 Agonism to Rescue APOE4-Induced Microglial Dysfunction | 0.690 | neurodegeneration | APOE4 targeting in neurodegeneration |
| TREM2-Astrocyte Communication in Microglial Dysfunction | 0.579 | neurodegeneration | Gene expression changes in aging mouse b |
| TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blo | 0.499 | neuroscience | Circuit-level neural dynamics in neurode |
| APOE and TREM2 interact to modulate age-dependent microglial | 0.467 | Alzheimer's disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.776
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Thera [PMID:40922457] | ["Eroglu E", "Harmanci N"] | Basic & clinical pharmacology | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease [PMID:26137544] | Macauley SL, Holtzman DM | EBioMedicine | 2015 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning microglial_dysfunction in their description or question text
Score: 0.499 · neuroscience · 2026-04-21
## Mechanistic Overview TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blood-Brain Barrier Breakdown starts fr
Score: 0.467 · Alzheimer's disease · 2026-04-23
## Mechanistic Overview APOE and TREM2 interact to modulate age-dependent microglial dysfunction starts from the claim t