Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about white_matter: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| aging | causes | phenotype | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive | 0.512 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| OPC differentiation blockade contributes to white matter deg | 0.495 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
| ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo | 0.493 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| White Matter Oligodendrocyte Protection via CXCL10 Inhibitio | 0.480 | neurodegeneration | Gene expression changes in aging mouse b |
| White Matter Vulnerability Prevention via Oligodendrocyte Pr | 0.468 | neurodegeneration | Gene expression changes in aging mouse b |
| White Matter Immune Checkpoint Restoration | 0.418 | neurodegeneration | Gene expression changes in aging mouse b |
| Oligodendrocyte White Matter Vulnerability | 0.398 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel [PMID:40988129] | Furlan R, Schaedelin S, Frederiksen JL, | Brain | 2026 | 0 |
| Overlapping autoimmunity and demyelination syndromes associated with TNF inhibit [PMID:41652144] | Daood R, Naffaa ME, Azrilin O, Hassan F, | Clin Rheumatol | 2026 | 0 |
| Pathogenic mechanisms of action of autoantibody-mediated central nervous system [PMID:41831629] | Lerch M, Irani SR, Ramanathan S | Autoimmun Rev | 2026 | 0 |
| TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-Ig [PMID:41921125] | Vilaseca A, Filippatou AG, Said Y, Sechi | Neurol Neuroimmunol Neuroinfla | 2026 | 0 |
| Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. [PMID:41925507] | Flanagan EP, Hemingway C | Continuum (Minneap Minn) | 2026 | 0 |
| Therapeutic updates in NMOSD and MOGAD: From present practice to future promise. [PMID:41927387] | Elosua-Bayés I, Cobo-Calvo A | Rev Neurol (Paris) | 2026 | 0 |
| MOGAD update: new phenotypes in the expanding clinical spectrum. [PMID:41942681] | Costello F, Burton JM | J Neurol | 2026 | 0 |
| Psychiatric comorbidities cluster early after onset in MOGAD: a cross-sectional [PMID:41956817] | Niederschweiberer M, Bakir C, Vorasoot N | J Neurol Neurosurg Psychiatry | 2026 | 0 |
| Understanding Further the Phenotypic Spectrum of Central Nervous System Inflamma [PMID:41957957] | Gulec B, Everest E, Tutuncu M, Bilge U, | Ann Clin Transl Neurol | 2026 | 0 |
| O-GlcNAcylation of UGDH regulates its activity and remodels the extracellular ma [PMID:41053177] | Lin B, Zhou J, Geng D, Chai S, Zhang X e | Cell Death Differ | 2026 | 0 |
| Mitochondrial NAD(+)-mediated mitophagy alleviates type I interferon response to [PMID:41231107] | Lan T, Shang D, Lin L, Wang H, Zou J et | Autophagy | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| Immune checkpoint inhibitor-associated inflammatory arthritis. [PMID:41800958] | Kim ST, Bass AR | Arthritis Rheumatol | 2026 | 0 |
| Oxoisoaporphine Alkaloid Piano-Stool Arene Ruthenium(II) Derivative: A cGAS-STIN [PMID:41910318] | Yang LM, Lu Y, Levine MS, Wang X, Shi YQ | J Am Chem Soc | 2026 | 0 |
| Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044] | Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e | Int J Parasitol | 2026 | 0 |
| CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Dri [PMID:41946147] | Norouzi S, Aulakh S | Transl Oncol | 2026 | 0 |