mechanism 7,227 words KG: ent-gene-eea87922
kind:mechanismsection:mechanismsstate:publishedtopic:alzheimersmicrogliacd8-t-cellswhite-matter
Contents

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

🔬 Protein Info
Gene Symbolent-gene-eea87922
Subcellular Localizationperiventricular and deep white matter regions in aging brains and AD patients [PMID-3834
Single-cell RNA sequencingDefined microglia and CD8+ T cell transcriptional states
Spatial transcriptomicsMapped cell-cell interactions in white matter
Flow cytometryQuantified T cell subsets in brain tissue
Electron microscopyVisualized synaptic contacts between CD8+ T cells and neurons
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48
Microglial Purinergic Reprogramming
Score: 0.48
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
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Blood-brain barrier transport mechanisms for antibody therap
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APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (13)

QTJD effects on macrophage polarization and inflammatory res
exploratory · proposed · Score: 0.95
P2RY12 inhibition in atherosclerosis mouse model
validation · proposed · Score: 0.90
VSMC cholesterol efflux and P2RY12 signaling
exploratory · proposed · Score: 0.90
CXCL10 biomarker analysis for CPSP prediction
clinical · proposed · Score: 0.90
P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90

Knowledge Graph (2 edges)

ent-gene-eea87922 data_in benchmark_ot_ad_answer_key:CD8
benchmark_ot_ad_answer_key:CD8 data_in ent-gene-eea87922