phenotype

aging

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aging: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10502Connections

3Hypotheses

30Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

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Progressive Supranuclear Palsy (PSP)

disease · 12907 words

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Pathway Diagram

graph TD
    aging["aging"] -->|"associated"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    aging["aging"] -->|"risk factor for"| age_related_diseases["age-related diseases"]
    style age_related_diseases fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    aging["aging"] -->|"promotes"| synaptic_dysfunction["synaptic dysfunction"]
    style synaptic_dysfunction fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    aging["aging"] -.->|"inhibits"| BECN1["BECN1"]
    style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    aging["aging"] -->|"risk factor for"| retinal_ganglion_cell_degenera["retinal ganglion cell degeneration"]
    style retinal_ganglion_cell_degenera fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    aging["aging"] -->|"causes"| white_matter_associated_microg["white matter-associated microglia"]
    style white_matter_associated_microg fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    aging["aging"] -.->|"inhibits"| PPARGC1A["PPARGC1A"]
    style PPARGC1A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"regulates"| aging["aging"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    senescence["senescence"] -->|"promotes"| aging["aging"]
    style senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    cellular_senescence["cellular senescence"] -->|"associated"| aging["aging"]
    style cellular_senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"prevents"| aging["aging"]
    style rapamycin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    kynurenine_pathway["kynurenine pathway"] -->|"associated"| aging["aging"]
    style kynurenine_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style aging fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (4772)

Target	Relation	Type	Str
neurodegeneration	associated_with	phenotype	1.00
age-related diseases	risk_factor_for	disease	0.95
cellular senescence	drives	process	0.95
synaptic dysfunction	promotes	phenotype	0.90
microglia	affects	cell_type	0.90
blood-brain barrier	affects	brain_region	0.90
neurons	affects	cell_type	0.90
unfolded protein response	involves	pathway	0.90
endothelial cells	affects	cell_type	0.90
oligodendrocytes	affects	cell_type	0.90
astrocytes	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
ferroptosis	involves	pathway	0.90
cortex	affects	brain_region	0.90
macrophages	affects	cell_type	0.90
neural stem cells	affects	cell_type	0.90
cGAS-STING	involves	pathway	0.90
skeletal muscle performance	suppresses	phenotype	0.90
BECN1	inhibits	gene	0.85
retinal ganglion cell degeneration	risk_factor_for	process	0.85
age-related neuropathy	causes	disease	0.85
CMKLR1-mediated metabolic reprogramming	promotes	process	0.85
oligodendrocyte dysfunction	causes (aging causes early transcriptomic changes in oligo)	mechanism	0.85
white matter-associated microglia	causes	cell_type	0.80
PPARGC1A	inhibits	gene	0.80
synaptic plasticity	involves	pathway	0.80
autophagy pathway	involves	pathway	0.80
pyroptosis	involves	pathway	0.80
white matter	affects	brain_region	0.80
AMPK signaling	involves	pathway	0.80
lipid metabolism	involves	pathway	0.80
thalamus	affects	brain_region	0.80
hypothalamus	affects	brain_region	0.80
axon	disrupts	organelle	0.80
NRF2	modulates	protein	0.75
microglia	activates	cell_type	0.72
hscs	associated_with	cell_type	0.72
calcium	regulates	protein	0.72
Alzheimer's disease	associated_with	disease	0.70
bioenergetics	inhibits	process	0.70
neuroplasticity	inhibits	process	0.70
neuronal resilience	inhibits	process	0.70
neuronal network activity	inhibits	process	0.70
neuronal calcium regulation	inhibits	process	0.70
Parkinson's disease	activates	disease	0.70
dopaminergic neurons	causes	cell_type	0.70
lipid droplets	activates	process	0.70
AMPK	inhibits	protein	0.70
PTN	regulates	protein	0.70
neurodegenerative diseases	causes	disease	0.70

Incoming (5730)

Source	Relation	Type	Str
MTOR	regulates	gene	0.95
senescence	promotes	process	0.95
cellular senescence	associated_with	process	0.95
mTOR	regulates	protein	0.90
rapamycin	prevents	drug	0.90
kynurenine pathway	associated_with	pathway	0.90
HAAO	therapeutic_target	gene	0.90
STAT6 deficiency	promotes	phenotype	0.90
NAD	activates	gene	0.90
DNA	associated_with	gene	0.90
senolytics	treats	compound	0.90
AMPK	activates	gene	0.90
NAD	implicated_in	gene	0.90
DNA	implicated_in	gene	0.90
RNA	associated_with	gene	0.90
DNA	disrupts	gene	0.90
DNA damage	promotes	process	0.90
P53	regulates	gene	0.88
TP53	associated_with	gene	0.88
DNA damage accumulation	promotes	process	0.88
senescence	downstream_of	process	0.88
mitophagy	protects_against	process	0.85
mTOR activation	promotes	process	0.85
cGAS-STING pathway	associated_with	pathway	0.85
ATBC	promotes	drug	0.85
inflammation	drives	process	0.85
NAD+ metabolism	regulates	pathway	0.85
senescent cells	promotes	cell_type	0.85
NRF2	prevents	gene	0.82
AMPK	regulates	protein	0.80
CGAS-STING signaling	participates_in	pathway	0.80
AMPK	modulates	gene	0.80
PI3K-AKT-mTOR	promotes	pathway	0.80
NAD	associated_with	gene	0.80
DNA	regulates	gene	0.80
AMPK	associated_with	gene	0.80
ALS	associated_with	gene	0.80
ROS	regulates	gene	0.80
STING	activates	gene	0.80
DNA	activates	gene	0.80
DNA	modulates	gene	0.80
BDNF	activates	gene	0.80
epigenetic changes	mediates	process	0.80
unfolded protein response	associated_with	process	0.78
P53	associated_with	gene	0.75
oxidative phosphorylation	associated_with	pathway	0.75
TP53	regulates	gene	0.75
mitochondrial-derived vesicles	associated_with	process	0.75
APOE	risk_factor_for	gene	0.75
HK-VDAC interaction	implicated_in	process	0.75

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
TREM2-SIRT1 Metabolic Senescence Circuit in Microglial Aging	0.587	neurodegeneration	Gene expression changes in aging mouse b
TNFRSF25-Mediated Aging Exosome Pathway Inhibition	0.412	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (30)

Scientific analyses that reference this entity

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.514

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Death receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer. [PMID:41605339]	Fang W, Du J, Xu Z, Liu Q, Liu Y et al.	Crit Rev Oncol Hematol	2026
Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES an [PMID:41693749]	Deng C, He Z, Zhu X	SAGE Open Med	2026
The involvement of TNFRSF25 in age-related hearing loss. [PMID:41882185]	Roche MV, Tang PC, Yan D, De Marchena MR	Hum Genet	2026
Maternal immune activation perturbs intestinal niche through microbial glyceroph [PMID:41926285]	Chang H, Zhu X, Shen C, Xu X, Ni Y et al	Cell Rep	2026
Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404]	Qi C, Sima W, Mao H, Hu E, Ge J et al.	Nat Commun	2025
Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329]	Morabito A, Zerlaut Y, Dhanasobhon D, Be	Neuron	2025
Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373]	Fisher J, Verhagen M, Long Z, Moissidis	Neuron	2024
Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473]	Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a	Adv Sci (Weinh)	2024
Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981]	Almeida VN	Ageing Res Rev	2024
Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213]	Mòdol L, Moissidis M, Selten M, Oozeer F	Neuron	2024
De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258]	Tang S, Conte V, Zhang DJ, Žedaveinytė R	Science	2024
Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868]	Xia D, Lianoglou S, Sandmann T, Calvert	Mol Neurodegener	2022
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149]	Fogaça MV, Wu M, Li C, Li XY, Picciotto	Mol Psychiatry	2021
Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235]	Ueda A, Shinkai S, Shiroma H, Taniguchi	Cell Rep Med	2021
Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092]	Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu	Front Neurosci	2020
Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546]	Hernández C, Simó R, European Consortium	Curr Med Chem	2013

aging

Understanding Entity Pages

Wiki Pages (21)

Aging-Associated Astrocytes

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

Parthanatos in Neurodegeneration

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Alzheimer's Disease Mechanism Index

Pathway Diagram

Outgoing (4772)

Incoming (5730)

Targeting Hypotheses (3)

Mentioning Analyses (30)

Are age-related static epigenetic patterns pathogenic or protective compensatory

What is the temporal sequence of TREM2 signaling transition from protective to i

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

What specific gene expression signatures in aging mouse brain predict human AD v

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

What specific gene expression signatures in aging mouse white matter predict hum

Which specific aging-related gene expression changes in mouse brain predict huma

Does CXCL10 inhibition compromise CNS immune surveillance during chronic treatme

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons

Investigate mechanisms of epigenetic reprogramming in aging neurons

What molecular mechanisms drive microglial senescence and the transition to dyst

Investigate mechanisms of epigenetic reprogramming in aging neurons

Epigenetic reprogramming in aging neurons

Neuroinflammation and microglial priming in early AD

epigenetic reprogramming aging neurons

Senescent cell clearance as neurodegeneration therapy

Quantitative proteomics of the aging synapse in early Alzheimer disease

Human connectome alterations and network-level dysfunction in Alzheimer disease

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic reprogramming in aging neurons

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Related Papers (16)