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Mechanism: Mutant Huntingtin Aggregation Pathway
mechanism
987 words
KG: Mutant Huntingtin Aggregation Pathway
2026-04-01
kind:
section:mechanisms
evidence:strongmechanism
section:mechanisms
state:published
mechanism-type:protein-aggregation
disease:huntingtons-disease
Contents
Mutant Huntingtin Aggregation Pathway
⚙
Mechanism Info
Name
Mutant Huntingtin Aggregation Pathway
Summary
Mechanistic pathway of mutant huntingtin (mHTT) protein aggregation in Huntington's disease - from polyglutamine expansion to oligomer formation and inclusion body generation
Knowledge Graph
Related Hypotheses (22)
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Autophagosome Maturation Checkpoint Control
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Synaptic Vesicle Tau Capture Inhibition
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APOE-Dependent Autophagy Restoration
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Circadian-Synchronized LRP1 Pathway Activation
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Cell-Type Specific TFEB Modulation
Score: 0.48
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
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Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
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Mitochondrial Transfer Pathway Enhancement
Score: 0.44
Mitochondrial RNA Granule Rescue Pathway
Score: 0.40
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
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TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
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Show 17 more
Related Analyses (30)
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