Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 94 pages matching "amyloid"

⚙️ amyloid-beta-metalloproteinasesKG

mechanism · 4,656 words · 181 hyp65 ana16 exp

🧪 PMN310 Anti-Amyloid for AD (NCT06750432)KG

clinical · 4,244 words · 51 hyp22 ana15 exp

⚙️ Amyloid Cascade PathwayKG

mechanism · 4,149 words · 200 hyp65 ana25 exp

⚙️ Amyloid-Beta Aggregation and Plaque FormationKG

mechanism · 3,820 words · 184 hyp65 ana23 exp

⚙️ Amyloid-beta Fibril Formation PathwayKG

mechanism · 3,761 words · 191 hyp65 ana22 exp

📊 Beta-Amyloid 42/40 Ratio - BiomarkerKG

biomarker · 3,667 words · 18 hyp11 ana18 exp

Amyloid Precursor Protein (APP)KG

entity · 3,485 words · 187 hyp60 ana23 exp

⚙️ Amyloid-beta Cellular Uptake PathwayKG

mechanism · 3,408 words · 200 hyp66 ana26 exp

🔀 APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal ChainKG

pathway · 3,076 words · 60 hyp55 ana95 exp

🔬 Amyloid-Beta (Aβ)KG

protein · 3,049 words · 51 hyp11 ana16 exp

📊 p-Tau Biomarker in Immunoglobulin Light Chain and Transthyretin AmyloidosisKG

biomarker · 2,836 words · 16 hyp5 ana15 exp

APOE contributes to Alzheimer's disease by regulating both beta-amyloid depositionKG

hypothesis · 2,704 words · 69 hyp10 ana48 exp

APOE contributes to Alzheimer's disease by regulating both beta-amyloid depositionKG

hypothesis · 2,704 words · 98 hyp72 ana102 exp

⚙️ brain-age-gap-amyloid-adKG

mechanism · 2,685 words · 213 hyp66 ana28 exp

⚙️ Cerebral Amyloid Angiopathy Pathway in NeurodegenerationKG

mechanism · 2,677 words · 293 hyp55 ana69 exp

💊 Anti-Amyloid TherapeuticsKG

therapeutic · 2,657 words · 102 hyp55 ana19 exp

🧪 AMDX-2011P Retinal Amyloid Tracer in Alzheimer's DiseaseKG

clinical · 2,654 words · 70 hyp27 ana61 exp

⚙️ Enzymes of Physiological Amyloidogenesis in NeurodegenerationKG

mechanism · 2,636 words · 278 hyp52 ana66 exp

⚙️ Amyloid-beta Oligomerization PathwayKG

mechanism · 2,599 words · 192 hyp65 ana18 exp

⚙️ amyloid-beta-cellular-uptakeKG

mechanism · 2,594 words · 194 hyp66 ana29 exp

⚙️ amyloid-cascade-hypothesisKG

mechanism · 2,586 words · 194 hyp65 ana20 exp

🧬 APP — Amyloid Precursor ProteinKG

gene · 2,551 words · 186 hyp42 ana24 exp

🏥 Cerebral Amyloid Angiopathy (CAA)KG

disease · 2,530 words · 23 hyp12 ana20 exp

Neuritic Amyloid Plaques — Histomorphologic Evidence of Pathologic Synergy in ADKG

hypothesis · 2,528 words · 15 hyp17 ana21 exp

remternetug-anti-amyloid-alzheimersKG

clinical_trial · 2,526 words · 23 hyp13 ana19 exp

⚙️ amyloid-cascade-pathwayKG

mechanism · 2,447 words · 203 hyp65 ana30 exp

💡 Dual Proteinopathy Immunotherapy: Aβ + pTau/pα-Syn BispecificKG

idea · 2,414 words · 2 hyp8 ana1 exp

⚙️ Acarbose Modulation of Alpha-Synuclein Amyloid FibrillationKG

mechanism · 2,373 words · 23 hyp48 ana12 exp

⚙️ Amyloid-Tau Synergistic Interaction HypothesisKG

mechanism · 2,372 words · 182 hyp65 ana18 exp

Pathologic Synergy Occurring in the Amygdala Between Amyloid Plaques and Tau/NFT May Facilitate the Transition from PART to ADKG

hypothesis · 2,355 words · 28 hyp21 ana29 exp

⚙️ Diffuse Amyloid Deposits in Alzheimer's DiseaseKG

mechanism · 2,321 words · 43 hyp24 ana58 exp

⚙️ Cerebral Amyloid Angiopathy: Mechanism and NeurodegenerationKG

mechanism · 2,287 words · 291 hyp55 ana69 exp

🔀 TREM2-Mediated Amyloid Clearance PathwayKG

pathway · 2,281 words · 97 hyp69 ana53 exp

⚙️ amyloid-hypothesisKG

mechanism · 2,274 words · 184 hyp65 ana17 exp

💊 Florbetapir (Amyvid) Amyloid PET ImagingKG

therapeutic · 2,230 words · 14 hyp10 ana17 exp

Mechanistic Proposal: Amyloid Plaque and Neurofibrillary Tangle Deposition is Essential for Accurate Modeling of AD in Mouse ModelsKG

hypothesis · 2,194 words · 23 hyp16 ana19 exp

⚙️ Amyloid vs Tau-First HypothesisKG

mechanism · 2,141 words · 187 hyp66 ana27 exp

📊 Soluble Amyloid Precursor Protein Beta (sAPPβ)KG

biomarker · 2,123 words · 25 hyp16 ana15 exp

⚙️ LRP1-Mediated Amyloid-Beta Clearance in NeurodegenerationKG

mechanism · 2,102 words · 298 hyp57 ana85 exp

Amyloid plaque and neurofibrillary tangle deposition is an essential component for accurate modeling...KG

hypothesis · 2,082 words · 183 hyp62 ana27 exp

🏥 Hereditary Transthyretin Amyloidosis (hATTR)KG

disease · 2,042 words · 3 hyp4 ana14 exp

⚙️ Amyloid-beta Fibril FormationKG

mechanism · 2,012 words · 180 hyp65 ana17 exp

⚙️ Amyloid Conformational StrainsKG

mechanism · 1,988 words · 188 hyp66 ana25 exp

In Alzheimer's disease, biomarker events occur in a specific temporal sequence: amyloid-β abnormalitKG

hypothesis · 1,933 words · 39 hyp22 ana53 exp

In Alzheimer's disease, biomarker events occur in a specific temporal sequence: amyloid-β abnormalitKG

hypothesis · 1,933 words · 34 hyp30 ana65 exp

⚙️ Tumor-Derived Cystatin C Enables Amyloid ClearanceKG

mechanism · 1,873 words · 153 hyp67 ana19 exp

⚙️ Anti-Amyloid Therapeutics: Successes, Failures, and Lessons LearnedKG

mechanism · 1,865 words · 125 hyp64 ana33 exp

Alzheimer's Disease Neuropathology is Defined by the Accumulation of Pathological Amyloid-Beta in the Form of Senile Plaques and Dystrophic Neurites, and Phosphorylated Tau Neurofibrillary TanglesKG

hypothesis · 1,801 words · 51 hyp32 ana69 exp

⚙️ Amyloid-Tau Synergistic Interaction Hypothesis in Alzheimer's DiseaseKG

mechanism · 1,774 words · 211 hyp73 ana72 exp

⚙️ Amyloid Clearance MechanismsKG

mechanism · 1,665 words · 48 hyp46 ana28 exp