protein 3,049 words KG: AMYLOIDBETA 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Amyloid-Beta (Aβ)

🔬 Protein Info
Gene SymbolAPP
AliasesAMYLOIDBETA
Chromosome21
Protein FamilyAmyloid precursor protein family
Functionis a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002].
Primary ExpressionExtracellular, membrane-associated
Subcellular LocalizationExtracellular, membrane-associated
UniProt IDP05067
GeneCardsAPP
Human Protein AtlasAPP
GeneAPP
PDB1IYT, 1BA4, 2BEG, 5OQV
Mol. Weight4 kDa (Aβ40/42)
Associated DiseasesAlzheimer's Disease, Cerebral Amyloid Angiopathy
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Aquaporin-4 Polarization Rescue
Score: 0.51

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (16)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.46
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.46
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.46
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.46
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.46

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 5 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 5 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 5 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 5 hypotheses