| Gene Symbol | TREM2 |
| Full Name | Mediated Amyloid Clearance Pathway |
| Aliases | Triggering Receptor Expressed on Myeloid cells 2, TREM-2 |
| Chromosome | 6p21.1 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | Lipid sensing; Debris clearance; Microglial activation |
| Mechanism of Action | Agonist antibodies that enhance TREM2 signaling to promote microglial function |
| Primary Expression | Microglia, Cerebral cortex, Hippocampus |
| Druggability | Low (0.42) |
| Clinical Stage | Phase II |
| Molecular Weight | 35 kDa |
| Amino Acids | 231 aa |
| Exons | 5 |
| Pathways | Innate immunity, Phagocytosis, DAP12-SYK signaling |
| UniProt ID | Q9NZC2 |
| NCBI Gene ID | 54209 |
| Ensembl ID | ENSG00000095970 |
| OMIM | 605086 |
| GeneCards | TREM2 |
| Human Protein Atlas | TREM2 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, ALZHEIMERS, AUTOPHAGY, Aging |
| Known Drugs/Compounds | lecanemab treatment, β-amyloid, phosphatidylserine, amyloid deposits, METFORMIN, Beta-Amyloid |
| Interactions | NLRP3, TLR4, GSDMD, MYD88, CD9, PSEN1 |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | TREM2-Dependent Microglial Senescence Transition TREM2-Dependent Astrocyte-Microglia Cross-talk in TREM2-mediated microglial tau clearance enhancemen (+32 more) |
| KG Connections | 3695 knowledge graph edges |
| Databases | GeneCardsHPASTRING |