biomarker 2,950 words KG: Ptau181 2026-03-25
kind:biomarkersection:biomarkersstate:publishedevidence:strong
Contents

Phosphorylated Tau 181 (p-tau 181)

🔬 Protein Info
Gene SymbolPTAU181
Chromosome17q21
GeneCardsPTAU181
Human Protein AtlasPTAU181
CDK5 (Cyclin-Dependent Kinase 5)Neuron-specific kinase activated in AD
Japanese cohortsAUC 0.89-0.93 for AD vs. controls [@japanese2022]
Chinese cohortsAUC 0.87-0.92, with similar cutoff values to Western populations [@chinese2023]
Korean cohortsAUC 0.90-0.95, p-tau 181 successfully distinguishes AD from MCI [@korean2023]
Associated DiseasesAlzheimer's Disease, CSF, ALS
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57

Related Analyses (21)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Mouse Cdk5, p35, and p39 mutations in neuronal migration
validation · proposed · Score: 0.80

Knowledge Graph (2 edges)

Ptau181 biomarker_for Alzheimer's Disease
Amino acid metabolism associated_with Ptau181