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Clinical_Trial: nct02605785-tau-pet-psp
clinical_trial
2,964 words
KG: PSP
Contents
nct02605785-tau-pet-psp
Knowledge Graph
Related Hypotheses (13)
Aquaporin-4 Polarization Rescue
Score: 0.73
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1q Subtype Switching
Score: 0.66
Sphingolipid Metabolism Reprogramming
Score: 0.66
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Netrin-1 Gradient Restoration
Score: 0.59
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Show 8 more
Related Analyses (4)
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Related Experiments (8)
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40
Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
Show 3 more
See Also (11)
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with
cdkn2a
gene · KG edge: associated_with
Genes
index · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Frontotemporal Dementia (FTD)
disease · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_in
Show 6 more
Knowledge Graph (12 edges)
PSP
downregulates
SV2A
PSP
co_discussed
TAU
PSP
co_discussed
T CELL
PSP
co_discussed
SYNAPSE
PSP
co_discussed
STING
PSP
co_discussed
TBI
PSP
co_discussed
VCP
PSP
co_discussed
SLEEP
PSP
co_discussed
SMPD1
PSP
co_discussed
SQSTM1
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