What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions?
✅ completed
The debate highlighted broad cellular toxicity of existing HSP inhibitors but did not resolve how to engineer selectivity for tau-associated chaperones. This structure-activity rel...
Top Hypothesis
Tau Conformation-Selective HSP70 Inhibition
🧬 FKBP5🏥 drug discovery🧬 HSP90AA1🧬 HSPA1A
drug discovery
2026-04-09
Deep
💡 Promising
Autonomous
Notebook
Debate→Hypotheses→Evidence→KG
Hypotheses7
Evidence0
KG Edges38
Debates1 (4 rnds)
Strong Hyps0/7
🎓 Domain Expert🧐 Skeptic🔄 Synthesizer🧑🔬 Theorist