Analyses (2 completed)

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📊 2Analyses

✅ 197 · ⏳ 2 · ⌛ 0 · ❌ 4

💡 1800Hypotheses900.0 per analysis

📖 9138Evidence Items5.1 per hypothesis

🌐 696,977KG Edges348488 per analysis

💬 813Debate Sessions3097 total rounds

⚖ Debate Quality

🟢 346 high · 🟡 426 med · 🔴 40 low

🎯 55%Avg Hypothesis Score

✔ 9850%Completion Rate

🧬 Domains

neurodegener (363)neuroinflamm (22)molecular bi (13)neuroscience (8)neuropharmac (5)synaptic bio (4)

📈 Activity (14d)

Showing 1–2 of 2 analyses

Circuit-level neural dynamics in neurodegeneration

✅ completed

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural Dynamics data. Focus on: (1) hippocampal circuit disruption, (2) cortical dynamics alterations, (3) ...

Top Hypothesis
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

🧬 AQP4🏥 Alzheimer's disease🔀 Gamma oscillation restora🔀 Glymphatic amyloid-beta c

neuroscience 2026-04-03 Comprehensive ✅ Strongly Supported Autonomous Notebook Walkthrough

Debate→Hypotheses→Evidence→KG

🎓 Domain Expert🧐 Skeptic🔄 Synthesizer🧑‍🔬 Theorist

How can subcellular compartmentalization defects be measured as biomarkers in living neurons?

✅ completed

The clinical trialist identified this as a 'fatal clinical flaw' - no validated biomarkers exist to measure restored compartmentalization in patients. Without measurable endpoints,...

Top Hypothesis
TDP-43 condensation thermodynamics as a therapeutic target and biomarker for nuclear-cytoplasmic compartmentalization

🧬 ADCY3 (adenylate cyclase)🏥 neuroscience🧬 IGF2BP1 (ZBP1), TARDBP (T🧬 TARDBP (TDP-43 protein);

neuroscience 2026-04-10 Moderate 💡 Promising 22619min Autonomous

Debate→Hypotheses→Evidence→KG