CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent SPP1 Transcription

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CD36 scavenger receptor binds Aβ42 oligomers, forming a signaling complex with TLR4/TLR6 that activates downstream NF-κB and AP-1 transcription factors, directly driving SPP1 promoter activation.