Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

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## **Molecular Mechanism and Rationale** The liquid-to-solid phase transition of ribonucleoprotein (RNP) granules represents a critical pathological mechanism underlying selective neuronal vulnerability in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This hypothesis centers on the differential susceptibility of specific RNP granules to pathological solidification based o