SASP-Mediated Complement Cascade Amplification
h-58e4635a
## Mechanistic Overview
SASP-Mediated Complement Cascade Amplification starts from the claim that modulating C1Q/C3 within the disease context of neurodegeneration can redirect a disease-relevant process. The original description reads: "**SASP-Mediated Complement Cascade Amplification in Alzheimer's Disease** **Overview: Senescence, Inflammation, and Synaptic Loss** Cellular senescence—a state of
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| neurodegeneration | 2080 | ±65 | 48-23-0 | 71 |
| tournament:top50 | 1500 | ±350 | 0-0-0 | 0 |
Ancestry (oldest → this)
(no parents — root hypothesis)
Descendants
1512 (12 matches)
1421 (4 matches)