TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation

h-76ea1f28

## Mechanistic Overview TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation starts from the claim that modulating TREM2/ACAT1/LXR within the disease context of neuroimmunology can redirect a disease-relevant process. The original description reads: "# TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation: A Unifying Mechanism for Microglial Dysfunction in Alzheimer's Disease ##