Closed-loop neuromodulation-inspired cytokine axis suppression to restore Cx43 hemichannel-mediated synaptic homeostasis via inflammatory interneuron crosstalk in cellular senescence

h-analogy-2be480e6

Like CCK interneuron neuromodulation restores gamma oscillations in Alzheimer's disease by addressing upstream protein aggregation-driven phagocytic dysregulation, targeting TNF-α/IL-1β-Cx43 hemichannel signaling may restore synaptic pruning homeostasis in senescence by modulating inflammatory interneuron crosstalk. Specifically, closed-loop inhibition of Cx43 hemichannel opening (via connexin mim