Closed-loop optogenetic targeting of PV interneurons to restore motor circuit inhibition and attenuate excitotoxicity-driven motor neuron degeneration in ALS

h-analogy-38e863ca

In AD, optogenetic PV interneuron activation restores theta-gamma coupling disrupted by amyloid-beta, preserving synaptic function. Analogously, in ALS, enhancing PV interneuron activity in motor cortex could reduce hyperexcitability and glutamatergic toxicity on motor neurons, potentially slowing degeneration. This predicts that PV-targeted optogenetic intervention will reduce motor neuron loss a