Closed-loop transcranial focused ultrasound targeting motor cortex SST interneurons to restore cortical oscillations via corticospinal excitability gating in ALS

h-analogy-410d3197

In Alzheimer's disease, SST interneurons in the entorhinal-hippocampal circuit gate gamma oscillations and synaptic plasticity. Analogously, in ALS, SST interneurons in the motor cortex regulate cortical excitability and oscillatory dynamics; modulating these cells via closed-loop focused ultrasound may restore pathological beta/gamma band desynchronization and reduce corticospinal hyperexcitabili