Microglial TBK1 Deficiency Triggers Senescence-Associated Secretory Phenotype in Frontotemporal Dementia

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Loss-of-function mutations in TBK1, a established risk factor for familial FTD, may trap microglia in a senescent, pro-inflammatory state characterized by SASP, analogous to the mechanism established in ALS. This microglial senescence could drive cortical neurodegeneration and accelerate disease progression in FTD. The prediction is that TBK1-deficient microglia in FTD models will exhibit upregula