Alpha-synuclein phosphorylation-dominated LLPS hijacks synaptic vesicle condensates driving Parkinson disease pathology

h-analogy-8eef2620

Like RBM45 in ALS, disease-modified alpha-synuclein undergoes altered LLPS behavior that dominantly rewires normal membraneless compartments. In PD neurons, phosphorylated (Ser129) and oxidative-modified alpha-synuclein forms aberrant, stable condensates at synaptic terminals that hijack synaptic vesicle clusters, displacing essential synaptic proteins (complexin, synaptotagmin-1) and vesicular pr