Astrocyte-targeted LNP-APOE4 silencing to restore lipid homeostasis and suppress TREM2-mediated neuroinflammation in neurodegeneration

h-analogy-90a0279a

In Alzheimer's disease, closed-loop optogenetic modulation of PV interneurons restores theta-gamma coupling by reducing amyloid-induced neuroinflammation. Analogously, astrocyte-selective APOE4 silencing via lipid nanoparticles (LNPs) may restore lipid homeostasis and reduce TREM2-dependent microglial activation in neurodegeneration. Both approaches target a disease-critical cell type to interrupt