TBK1 Insufficiency in Alzheimer Microglia Drives a Senescence-Like Inflammatory State That Accelerates Tau Pathology

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In ALS, TBK1 loss-of-function traps microglia in a senescence-like, SASP-producing state that drives neurodegeneration. By analogy, partial TBK1 insufficiency in AD microglia may similarly lock cells into an aged, pro-inflammatory transcriptional program, shifting them from a protective amyloid-clearance phenotype toward a destructive,tau-propagating one. This predicts that microglial TBK1 activit