TDP-43 Liquid-Liquid Phase Separation Dominance in Stress Granules Predisposes to Pathological Aggregation in Alzheimer's Disease

h-analogy-9e00d99e

Modified TDP-43 (phosphorylation, ubiquitination) in AD neurons undergoes altered LLPS behavior, forming pathologically stable stress granules that outcompete transient, functional granules. This TDP-43 condensate dominance displaces essential RNA processing factors (TIA1, G3BP1, hnRNP A1) into aggregation-prone states, mirroring the RBM45 hijacking mechanism observed in ALS. The prediction is tha