FUS Phase Separation Dominance in FTD-TDP: Aberrant Condensate Hijacking of RNA Processing Droplets

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In ALS motor neurons, disease-modified RBM45 hijacks RNA processing condensates through altered LLPS behavior, displacing TDP-43 into pathological aggregates. Similarly, in Frontotemporal dementia (particularly FTD-TDP subtype), FUS (Fused in Sarcoma) - another low-complexity domain RNA-binding protein - undergoes post-translational modifications (phosphorylation, acetylation) that stabilize its c