TREM2-complement-amyloid axis as therapeutic target for protein aggregation disorders

h-analogy-ceb122df

The TREM2-complement-amyloid signaling axis identified in Alzheimer's disease (where TREM2 activation on microglia promotes amyloid clearance via complement-mediated synaptic pruning regulation) shares structural homology with the protein aggregation pathology in the target unknown disease. Specifically, TREM2-mediated complement activation represents a conserved microglial mechanism for regulatin