TREM2-Modulating LNPs for Neurodegeneration: Cell-Type-Specific Immunometabolic Targeting via Microglial Modulation

h-analogy-daabed82

Closed-loop optogenetic targeting of PV interneurons in AD restores circuit dysfunction through TREM2-mediated microglial immunometabolic regulation. Analogously, astrocyte-selective APOE4 silencing in neurodegeneration via lipid nanoparticles could be reframed as a TREM2-targeted microglial strategy that leverages the shared neuroinflammation-oxidative stress axis. Specifically, TREM2-activating