Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activation

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**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) represents a critical microglial receptor that orchestrates the clearance of pathological protein aggregates, including extracellular tau species. TREM2 is a single-pass transmembrane glycoprotein expressed predominantly on microglia in the central nervous system, functioning as a pattern recognitio