Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake

h-c90cca1826

**Molecular Mechanism and Rationale** The pathological spread of tau protein aggregates represents a central mechanism underlying the progression of Alzheimer's disease and related tauopathies. Recent advances have elucidated the critical role of heparan sulfate proteoglycans (HSPGs) in facilitating the uptake of extracellular tau species by neurons, establishing these cell surface receptors as c