Competitive APOE4 Domain Stabilization Peptides

h-d0a564e8

**Molecular Mechanism and Rationale** The apolipoprotein E epsilon 4 (APOE4) allele represents the strongest genetic risk factor for late-onset Alzheimer's disease, carried by approximately 25% of the population and increasing AD risk by 3-fold in heterozygotes and 12-fold in homozygotes. The molecular basis for APOE4's pathogenicity lies in its unique structural instability compared to the prote