Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration

h-var-08a4d5c07a

## Mechanistic Overview Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration proposes that intestinal dysbiosis creates systemic NLRP3 inflammasome priming through bacterial lipopolysaccharide (LPS) translocation, followed by secondary activation triggers in the central nervous system. Circulating LPS binds to Toll-like receptor 4 (TLR4) on peripheral monocytes and bra