H6-V1: Aberrant eIF2α Phosphorylation Drives Mitochondrial Translation Dysfunction

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The eukaryotic initiation factor 2α (eIF2α) phosphorylation pathway critically regulates both cytoplasmic and mitochondrial protein synthesis, with mitochondrial translation dysfunction representing a key pathogenic mechanism in neurodegeneration. While cytoplasmic eIF2α phosphorylation by PERK initially serves as an adaptive response to ER stress, sustained phosphorylation creates a secondary pat