Cortico-Striatal Synchrony Restoration via NMDA Modulation

h-var-5e33600319

**Molecular Mechanism and Rationale** The cortico-striatal circuit represents one of the most sophisticated neural networks governing motor control, habit formation, and executive function through precisely orchestrated synaptic communication. At the molecular level, this circuit depends critically on GluN2B-containing NMDA receptors (encoded by GRIN2B) positioned strategically at cortico-striata