Epigenetic Silencing of Tumor Suppressor Genes in Cancer Progression

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This hypothesis proposes that hypermethylation of CpG islands in the promoter region of the TP53 tumor suppressor gene leads to transcriptional silencing and subsequent loss of p53 function in colorectal cancer development. The p53 protein normally acts as a critical checkpoint regulator in the cell cycle, inducing apoptosis or cell cycle arrest in response to DNA damage. When TP53 promoter hyperm