Novel Hypothesis on Metabolic Dysregulation in Neurodegeneration

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This hypothesis proposes that mitochondrial dysfunction in astrocytes represents a critical upstream driver of neurodegeneration in Alzheimer's disease through disruption of lactate shuttling to neurons. Specifically, we hypothesize that accumulation of amyloid-beta oligomers selectively impairs the mitochondrial respiratory chain complex I in astrocytes, leading to reduced ATP production and comp