ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE Peroxidation
h-var-97b18b880d
## Molecular Mechanism and Rationale
ALOX15 (15-lipoxygenase) catalyzes the stereospecific oxygenation of polyunsaturated fatty acids (PUFAs) esterified to phosphatidylethanolamine (PE) at the sn-2 position, generating 15-hydroperoxyeicosatetraenoic acid-PE (15-HpETE-PE) and other lipid hydroperoxides that serve as initiating signals for ferroptosis. In oligodendrocytes, which maintain exceptiona
Elo ratings (across arenas)
| Arena | Rating | RD | W-L-D | N |
|---|---|---|---|---|
| loop:loop-e96d7318f40f | 1422 | ±295 | 0-1-0 | 1 |
| global | 1265 | ±138 | 2-8-0 | 10 |
| alzheimers | 1028 | ±193 | 0-4-0 | 4 |
Ancestry (oldest → this)
mutate · gen 2
parent: h-seaad-v4-26ba859b
Replaces iron-catalyzed Fenton chemistry in microglia with enzymatic ALOX15-driven lipid peroxidation in oligodendrocytes, shifting both the mechanism dimension (enzymatic vs. non-enzymatic) and the c
Descendants
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