Astrocytic Complement Regulator Release Modulates Synaptic Vulnerability (CD55/CD46)

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**Molecular Mechanism and Rationale** Astrocytic release of soluble complement regulators CD55 and CD46, rather than membrane-bound expression, represents a dynamic mechanism for spatiotemporal control of complement-mediated synaptic pruning. Astrocytes constitutively express high levels of CD55 and CD46, which undergo metalloproteinase-mediated shedding via ADAM10 and ADAM17 cleavage at defined