ACSL4-Mediated Neuroinflammatory Amplification in Disease-Associated Microglia

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ACSL4 (acyl-CoA synthetase long-chain family member 4) drives neuroinflammatory amplification in disease-associated microglia through arachidonic acid (AA) metabolism and eicosanoid signaling rather than ferroptotic cell death. In this mechanism, ACSL4 upregulation in DAM microglia increases AA-CoA pools that serve as substrates for cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO), generating pr