LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Priming Engine in Disease-Associated Microglia

h-var-e4cae9d286

## Molecular Mechanism and Rationale LPCAT3-mediated Lands cycle remodeling represents a critical regulatory node for membrane PUFA incorporation that operates through direct lysophospholipid acylation, bypassing the energy-intensive CoA-ligation step required by ACSL4-dependent de novo synthesis. Upon inflammatory activation, disease-associated microglia upregulate LPCAT3 expression through NF-κ