GABRA1 Protein

GABRA1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GABRA1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>GABA-A Receptor Alpha1 Subunit</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>GABRA1</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P14867</td>
</tr>
<tr>
<td class="label">PDB ID</td>
<td>1DW6, 5OSM</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>51 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Plasma membrane (synaptic and extrasynaptic)</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>Cys-loop ligand-gated ion channel receptor family</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">Diazepam</td>
<td>Positive allosteric modulator</td>
</tr>
<tr>
<td class="label">Lorazepam</td>
<td>Positive allosteric modulator</td>
</tr>
<tr>
<td class="label">Zolpidem</td>
<td>Selective agonist</td>
</tr>
<tr>
<td class="label">Phenobarbital</td>
<td>Allosteric modulator</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">Flumazenil</td>
<td>Competitive antagonist</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/alzheimer" style="color:#ef9a9a">ALZHEIMER</a>, <a href="/wiki/alzheimer's"

GABRA1 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GABRA1 Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>GABA-A Receptor Alpha1 Subunit</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>GABRA1</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>P14867</td>
</tr>
<tr>
<td class="label">PDB ID</td>
<td>1DW6, 5OSM</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>51 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Plasma membrane (synaptic and extrasynaptic)</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>Cys-loop ligand-gated ion channel receptor family</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">Diazepam</td>
<td>Positive allosteric modulator</td>
</tr>
<tr>
<td class="label">Lorazepam</td>
<td>Positive allosteric modulator</td>
</tr>
<tr>
<td class="label">Zolpidem</td>
<td>Selective agonist</td>
</tr>
<tr>
<td class="label">Phenobarbital</td>
<td>Allosteric modulator</td>
</tr>
<tr>
<td class="label">Drug</td>
<td>Type</td>
</tr>
<tr>
<td class="label">Flumazenil</td>
<td>Competitive antagonist</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/alzheimer" style="color:#ef9a9a">ALZHEIMER</a>, <a href="/wiki/alzheimer's" style="color:#ef9a9a">ALZHEIMER'S</a>, <a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">ALZHEIMER'S DISEASE</a>, <a href="/wiki/anxiety" style="color:#ef9a9a">ANXIETY</a></td>
</tr>
<tr>
<td class="label">SciDEX Hypotheses</td>
<td><a href="/hypothesis/h-49791706" style="color:#ce93d8" title="Score: 0.40">Biorhythmic Interference via Controlled ...</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">130 edges</a></td>
</tr>
</table>

Pathway Diagram

Gabra1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

Structure

The GABA-A receptor alpha1 subunit is a member of the Cys-loop ligand-gated ion channel family. Each subunit consists of:

• Extracellular N-terminal domain: Contains the characteristic Cys-loop motif and binding sites for GABA and benzodiazepines
• Transmembrane domains: Four hydrophobic helices (M1-M4) that form the ion channel pore
• Intracellular loop: Between M3 and M4, involved in trafficking and modulation
• C-terminal extracellular domain

Normal Function

Receptor Composition

• The alpha1 subunit is the most abundant GABA-A receptor subunit
• Forms receptors with distinct pharmacological properties
• Confers benzodiazepine sensitivity when combined with gamma2 subunit

Physiological Roles

• Mediates fast inhibitory synaptic transmission
• Regulates neuronal excitability throughout the CNS
• Controls sedation, anxiolysis, muscle relaxation, and anticonvulsant effects
• Important for sleep architecture

Role in Disease

Epilepsy

• GABRA1 mutations: Cause genetic epilepsy syndromes (JME,CAE,LGS)
• Mechanism: Loss-of-function mutations reduce inhibitory signaling
• Therapeutic target: Benzodiazepines enhance receptor function

Neurodegenerative Diseases

• Alzheimer's Disease: [Amyloid-beta](/proteins/amyloid-beta) affects GABA-A receptor function and localization
• Parkinson's Disease: Altered inhibitory signaling in basal ganglia circuits
• ALS: Changes in cortical inhibitory networks

Therapeutic Targeting

Agonists

Antagonists

Key Publications

See Also

• [GABRA1 Gene](/proteins/gabra1-protein)
• [GABA-A Receptor](/proteins/gaba-a-receptor)
• [GABA Signaling in Neurodegeneration](/mechanisms/gaba-imbalance)
• [Epilepsy](/diseases/epilepsy)
• [Alzheimer's Disease](/diseases/alzheimers-disease)

External Links

• [UniProt: GABRA1](https://www.uniprot.org/uniprot/P14867)
• [PDB: 1DW6](https://www.rcsb.org/structure/1DW6)
• [NCBI Protein: GABRA1](https://www.ncbi.nlm.nih.gov/protein/P14867)

Background

The study of Gabra1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

Related Hypotheses

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

• [Biorhythmic Interference via Controlled Sleep Oscillations](/hypothesis/h-49791706) — <span style="color:#ffd54f;font-weight:600">0.40</span> · Target: GABRA1